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Pathways Recommended: GPCR/G Protein
Results for "

<i>Rhododendron molle<_i> G. Don

" in MedChemExpress (MCE) Product Catalog:

5861

Inhibitors & Agonists

22

Screening Libraries

207

Fluorescent Dye

235

Biochemical Assay Reagents

707

Peptides

65

MCE Kits

163

Inhibitory Antibodies

829

Natural
Products

752

Recombinant Proteins

204

Isotope-Labeled Compounds

227

Antibodies

96

Click Chemistry

331

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122949
    Momordicine I

    		DGK Metabolic Disease
    Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .
    Momordicine I
  • HY-103351
    Cathepsin G Inhibitor I

    		Cathepsin Inflammation/Immunology
    Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC50=53 nM; Ki=63 nM) .
    Cathepsin G Inhibitor I
  • HY-148016
    I-287

    		Protease Activated Receptor (PAR) ERK Inflammation/Immunology
    I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research .
    I-287
  • HY-162091
    Topoisomerase I inhibitor 13

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 13 (Compound G11) is a Topo I inhibitor that inhibits cancer cell proliferation. Topoisomerase I inhibitor 13 significantly inhibits tumor growth in vivo .
    Topoisomerase I inhibitor 13
  • HY-N1057
    Plantarenaloside

    Yuheinoside

    		 Others Others
    Plantarenaloside is an iridoid glucoside that can be isolated from Leucocarpus perfoliatus G. DON .
    Plantarenaloside
  • HY-143265
    Topoisomerase I inhibitor 2

    		Topoisomerase Apoptosis Caspase Cancer
    Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect .
    Topoisomerase I inhibitor 2
  • HY-147985
    hCA I-IN-1

    		Carbonic Anhydrase Cancer
    hCA I-IN-1 (Compound 6q) is a human carbonic anhydrase I (hCA I) inhibitor with Ki values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .
    hCA I-IN-1
  • HY-147986
    hCA I-IN-2

    		Carbonic Anhydrase Cancer
    hCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with Ki values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .
    hCA I-IN-2
  • HY-156969
    Topoisomerase I inhibitor 11

    		Topoisomerase Btk Cancer
    Topoisomerase I inhibitor 11 is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 11 can bind to BTK .
    Topoisomerase I inhibitor 11
  • HY-P1396
    GRK2i

    		G Protein-coupled Receptor Kinase (GRK) Others
    GRK2i is a Gβγ-inhibitory peptide that selectively prevents Gβγ-mediated signaling. GRK2i corresponds to the Gβγ-binding domain of GRK2 (G-protein-coupled receptor kinase 2) .
    GRK2i
  • HY-N0047
    Polyphyllin I
    1 Publications Verification

    		 JNK mTOR Akt PDK-1 Autophagy Apoptosis Cancer
    Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
    Polyphyllin I
  • HY-N12370
    Tenaxin I

    		Others Others
    Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity .
    Tenaxin I
  • HY-N0047R
    Polyphyllin I (Standard)

    		JNK mTOR Akt PDK-1 Autophagy Apoptosis Cancer
    Polyphyllin I (Standard) is the analytical standard of Polyphyllin I. This product is intended for research and analytical applications. Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
    Polyphyllin I (Standard)
  • HY-146437
    Topoisomerase I inhibitor 6

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .
    Topoisomerase I inhibitor 6
  • HY-P1032F
    Biotinyl-Angiotensin I (human, mouse, rat)

    		Endogenous Metabolite Endocrinology
    Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE) .
    Biotinyl-Angiotensin I (human, mouse, rat)
  • HY-149002
    Topoisomerase I/II inhibitor 4

    		Topoisomerase Apoptosis Cancer
    Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research .
    Topoisomerase I/II inhibitor 4
  • HY-P1396A
    GRK2i TFA

    		G Protein-coupled Receptor Kinase (GRK) Others
    GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist .
    GRK2i TFA
  • HY-143266
    Topoisomerase I inhibitor 3

    		Topoisomerase Apoptosis Cancer
    Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .
    Topoisomerase I inhibitor 3
  • HY-N15046
    Barminomycin I

    		Others Cancer
    Barminomycin I shows a strong inhibition of P388 leukemia cells with IC50 of about 0.00001 g/mL .
    Barminomycin I
  • HY-146497
    Topoisomerase I inhibitor 7

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones .
    Topoisomerase I inhibitor 7
  • HY-P3006
    Des-Leu10-angiotensin I

    		Drug Metabolite Cardiovascular Disease
    Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell .
    Des-Leu10-angiotensin I
  • HY-150685
    Topo I/COX-2-IN-1

    		Topoisomerase Prostaglandin Receptor Apoptosis Inflammation/Immunology Cancer
    Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity .
    Topo I/COX-2-IN-1
  • HY-P10925A
    I-67

    		β-catenin Cancer
    I-67, a structural isomer of I-66 (HY-P10925), is a potent β-catenin inhibitor with an IC50 of <50 nM. I-67 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-67 shows anticancer effects .
    I-67
  • HY-153340
    I-152

    		Keap1-Nrf2 Metabolic Disease
    I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties .
    I-152
  • HY-146655
    Glyoxalase I inhibitor 3

    		Glyoxalase (GLO) Cancer
    Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety .
    Glyoxalase I inhibitor 3
  • HY-E70040
    Endoglycoceramidase I (EGCase I)

    		Endogenous Metabolite Metabolic Disease
    Endoglycoceramidase I (EGCase I) is a glycosidase, is often used in biochemical studies. Endoglycoceramidase I catalyzes a transglycosylation reaction, which transfers the sugar moiety of GSLs to the primary hydroxyl group of several 1-alkanols .
    Endoglycoceramidase I (EGCase I)
  • HY-168603
    AChE/CA I-IN-1

    		Cholinesterase (ChE) Carbonic Anhydrase Neurological Disease
    AChE/CA I-IN-1 (Compound 2g) is the inhibitor for AChE and hCA I with Ki of 1.85 and 0.53 µM. AChE/CA I-IN-1 exhibits potential application in researches about Alzheimer's disease, glaucoma, and epilepsy .
    AChE/CA I-IN-1
  • HY-P10925
    I-66

    		β-catenin Cancer
    I-66 is a potent β-catenin inhibitor with an IC50 of <50 nM. I-66 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-66 shows anticancer effects .
    I-66
  • HY-P5798
    Fasciculin-I

    FAS-I

    		 Cholinesterase (ChE) Neurological Disease
    Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .
    Fasciculin-I
  • HY-P2774
    Glyoxalase I

    Glo-I

    		 Biochemical Assay Reagents Others
    Glyoxalase I (Glo-I) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Glyoxalase I
  • HY-131577A
    Neutral protease I

    Dispase I

    		 Collagen Others
    Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .
    Neutral protease I
  • HY-P5179
    Huwentoxin I

    HWTX-I

    		 Calcium Channel Sodium Channel Neurological Disease
    Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively .
    Huwentoxin I
  • HY-NP072
    Maackia Amurensis Lectin I

    MAL I

    		 Fluorescent Dye Others
    Maackia Amurensis Lectin I (MAL I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Maackia Amurensis Lectin I (MAL I) is a biological material or organic compound that can be used in life science research .
    Maackia Amurensis Lectin I
  • HY-NP079
    Ricinus Communis Agglutinin I

    RCA I

    		 Fluorescent Dye Others
    Ricinus Communis Agglutinin I (RCA I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ricinus Communis Agglutinin I (RCA I) is a biological material or organic compound that can be used in life science research .
    Ricinus Communis Agglutinin I
  • HY-NP090
    Ulex Europaeus Agglutinin I

    UEA I

    		 Fluorescent Dye Others
    Ulex Europaeus Agglutinin I (UEA I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) is a biological material or organic compound that can be used in life science research .
    Ulex Europaeus Agglutinin I
  • HY-N12073
    Monofucosyllacto-N-hexaose I

    MFLNH I

    		 Others Others
    Monofucosyllacto-N-hexaose I (MFLNH I) is a composition of human milk oligosaccharide .
    Monofucosyllacto-N-hexaose I
  • HY-144774
    Topoisomerase I inhibitor 5

    		Topoisomerase DNA/RNA Synthesis Apoptosis Cancer
    Topoisomerase I inhibitor 5 is an effective topoisomerase inhibitor with IC50 value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin .
    Topoisomerase I inhibitor 5
  • HY-100738
    Ubiquitin Isopeptidase Inhibitor I, G5
    5 Publications Verification

    NSC144303

    		 Apoptosis Cancer
    Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
    Ubiquitin Isopeptidase Inhibitor I, G5
  • HY-136538
    LQZ-7I

    		Survivin Cancer
    LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors .
    LQZ-7I
  • HY-148161
    L82-G17

    		DNA/RNA Synthesis Cancer
    L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity .
    L82-G17
  • HY-P3055
    Dendrotoxin-I

    DTX-I

    		 Potassium Channel Neurological Disease Cancer
    Dendrotoxin-I (DTX-I) is a potent K + channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .
    Dendrotoxin-I
  • HY-168739
    Topoisomerase I inhibitor 17

    		Topoisomerase Reactive Oxygen Species Apoptosis Survivin Bcl-2 Family IAP DNA/RNA Synthesis Cancer
    Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, γH2AX). Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice .
    Topoisomerase I inhibitor 17
  • HY-N11172
    Schibitubin I

    		Others Neurological Disease
    Schibitubin I is a lignin. Schibitubin I has neuroprotective activity. Schibitubin I can be isolated from the fruits of Schisandra bicolor var. tuberculata .
    Schibitubin I
  • HY-153151
    Fmoc-DON-Boc

    		Drug Intermediate Cancer
    Fmoc-DON-Boc (Compound 8b) is an Fmoc-protected compound that can be used for the synthesis of proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357). DON is a glutamine antagonist .
    Fmoc-DON-Boc
  • HY-E70280
    Recombinant endoglycoceramidase I

    rEGCase I

    		 Biochemical Assay Reagents Metabolic Disease
    Recombinant endoglycoceramidase I (rEGCase I) is a glycosidase that catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides. Recombinant endoglycoceramidase I catalyzes a transglycosylation reaction, which transfers the sugar moiety of glycosphingolipids (GSLs) to the primary hydroxyl group of several 1-alkanols .
    Recombinant endoglycoceramidase I
  • HY-W035090
    Chloro(trimethylphosphine)gold(I)

    (Trimethylphosphine)gold(I) chloride

    		 Biochemical Assay Reagents Endogenous Metabolite
    Chloro(trimethylphosphine)gold(I) ((Trimethylphosphine)gold(I) chloride) is a metal complex with antitumor activity. Chloro(trimethylphosphine)gold(I) has been studied as a potential chemotherapeutic compound in cancer inhibition. Chloro(trimethylphosphine)gold(I) can also be used in organic synthesis reactions as a catalyst to improve reaction efficiency. The biocompatibility of Chloro(trimethylphosphine)gold(I) makes it promising for application in medicine and materials science.
    Chloro(trimethylphosphine)gold(I)
  • HY-NP068
    Griffonia (Bandeiraea) Simplicifolia Lectin I

    GSL I

    		 Fluorescent Dye Others
    Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) is a biological material or organic compound that can be used in life science research .
    Griffonia (Bandeiraea) Simplicifolia Lectin I
  • HY-P3446A
    Big Gastrin I (human) TFA

    		Cholecystokinin Receptor Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Big Gastrin I, human (TFA) is a gastrointestinal hormone consisting of 34 amino acids. Big Gastrin I, human (TFA) can be used as a potential substance for the study of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological diseases or cardiovascular diseases .
    Big Gastrin I (human) TFA
  • HY-N12316
    Goshuyuamide I

    		Others Others
    Goshuyuamide-I (compound 4) is a kind of alkaloid. Goshuyuamide-I can be isolated from the fruits of Euodia rutaecarpa. Goshuyuamide-I can be used in the research of analgesics .
    Goshuyuamide I
  • HY-121934
    BH3I-2'

    		Drug Derivative Cancer
    BH3I-2' is the BH3I-2 analogue. BH3I-2 is a Bcl-2 family inhibitor. BH3I-2' can be used for various studies .
    BH3I-2'

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